Mechanism of Action
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. Cholesterol and triglycerides circulate in the bloodstream as part of lipoprotein complexes. With ultracentrifugation, these complexes separate into HDL (high-density lipoprotein), IDL (intermediate-density lipoprotein), LDL (low-density lipoprotein), and VLDL (very-low-density lipoprotein) fractions. Triglycerides (TG) and cholesterol in the liver are incorporated into VLDL and released into the plasma for delivery to peripheral tissues. LDL is formed from VLDL and is catabolized primarily through the high-affinity LDL receptor. Clinical and pathologic studies show that elevated plasma levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipoprotein B (apo B) promote human atherosclerosis and are risk factors for developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk.
Pharmacokinetics and Drug Metabolism
Absorption: maximum plasma concentrations occur within 1 to 2 hours
Distribution: Mean volume of distribution of atorvastatin is approximately 381 liters. Atorvastatin is ≥98% bound to plasma proteins.
Metabolism: metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
Excretion:eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
1.Prevention of Cardiovascular Disease
Muscle problems, Liver problems
Comments: Hi! this is my first featured drug for this blog. I may not write everything from the source. I will just highlight those information i think important to us. Ang mahal ng gamot na ito. Magkano na kaya ito sa botika?