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Featured Drug: Diazepam


Popular Brands: Valium, Novodipam, Relanium, Seduxen, Stesolid, Betapam

Diazepam is a benzodiazepine derivative. Chemically, Diazepam is 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. It is a colorless crystalline compound, and is insoluble in water.

Mechanism of Action
Diazepam is a benzodiazepine that binds to a specific subunit on the GABAA receptor at a site that is distinct from the binding site of the endogenous GABA molecule.[19][20] The GABAA receptor is an inhibitory channel which, when activated, decreases neuronal activity.

Because of the role of diazepam as a positive allosteric modulator of GABA, when it binds to benzodiazepine receptors it causes inhibitory effects. This arises from the hyperpolarization of the post-synaptic membrane owing to the control exerted over negative chloride ions by GABAA receptors.

Side effects

* Somnolence
* Suppression of REM sleep
* Addiction
* Impaired motor function
o Impaired coordination
o Impaired balance
o Dizziness and nausea
* Depression
* Impaired learning
* Anterograde amnesia (especially pronounced in higher doses)
* Cognitive deficits
* Reflex tachycardia

Diazepam may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

In the Philippines, prescription with S2 license is required before you can avail this medication.

source: drugs.com, wikipedia

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