Popular Brands: Valium, Novodipam, Relanium, Seduxen, Stesolid, Betapam
Diazepam is a benzodiazepine derivative. Chemically, Diazepam is 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. It is a colorless crystalline compound, and is insoluble in water.
Mechanism of Action
Diazepam is a benzodiazepine that binds to a specific subunit on the GABAA receptor at a site that is distinct from the binding site of the endogenous GABA molecule. The GABAA receptor is an inhibitory channel which, when activated, decreases neuronal activity.
Because of the role of diazepam as a positive allosteric modulator of GABA, when it binds to benzodiazepine receptors it causes inhibitory effects. This arises from the hyperpolarization of the post-synaptic membrane owing to the control exerted over negative chloride ions by GABAA receptors.
* Suppression of REM sleep
* Impaired motor function
o Impaired coordination
o Impaired balance
o Dizziness and nausea
* Impaired learning
* Anterograde amnesia (especially pronounced in higher doses)
* Cognitive deficits
* Reflex tachycardia
Diazepam may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
In the Philippines, prescription with S2 license is required before you can avail this medication.
source: drugs.com, wikipedia